Vaccines against Tuberculosis: Where Are We and Where Do We Need to Go?
نویسندگان
چکیده
In this review we discuss recent progress in the development, testing, and clinical evaluation of new vaccines against tuberculosis (TB). Over the last 20 years, tremendous progress has been made in TB vaccine research and development: from a pipeline virtually empty of new TB candidate vaccines in the early 1990s, to an era in which a dozen novel TB vaccine candidates have been and are being evaluated in human clinical trials. In addition, innovative approaches are being pursued to further improve existing vaccines, as well as discover new ones. Thus, there is good reason for optimism in the field of TB vaccines that it will be possible to develop better vaccines than BCG, which is still the only vaccine available against TB.
منابع مشابه
Multiantigenic subunitary vaccines against tuberculosis in clinical trials: Where do we stand and where do we need to go?
The idea of presenting this commentary is to bring attention to the current status of clinical tests from several multiantigen vaccine candidates based on proteins produced by means of genetic engineering and molecular biology approaches and to suggest how new emerging technologies (OMICs) and bioinformatics might benefit vaccine development for better control of tuberculosis.
متن کاملA Characterization of the Entropy--Gibbs Transformations
Let h be a finite dimensional complex Hilbert space, b(h)+ be the set of all positive semi-definite operators on h and Phi is a (not necessarily linear) unital map of B(H) + preserving the Entropy-Gibbs transformation. Then there exists either a unitary or an anti-unitary operator U on H such that Phi(A) = UAU* for any B(H) +. Thermodynamics, a branch of physics that is concerned with the study...
متن کاملLiposomes containing the imiquimod adjuvant as a vaccine in the cutaneous leishmaniasis model
Objective(s): Attempts to produce vaccines for leishmaniasis need adjuvants to trigger the kind of immune reaction required for protection. In this study, we examined the properties of the TLR7 agonist imiquimod, a vaccine adjuvant, making use of a live model of infection where the immune reactions could be identified prior to and following the challenge of infection. Materials and Method...
متن کاملPnm-25: The Importance of Reproductive Health
a:4:{s:10:"Background";s:797:"Reproductive health is defined as a state of physical, mental, and social well-being in all matters relating to the reproductive system, at all stages of life. Good reproductive health implies that people are able to have a satisfying and safe sex life, the capability to reproduce and the freedom to decide if, when, and how often to do so. Men and women should be i...
متن کامل